Automated Biodecontamination Chambers for Material Airlocks and Controlled Environments

Integrated Hybrid Hydrogen Peroxide™ Technology for Material Airlocks and Controlled Environments

Most facilities integrate CURIS Hybrid Hydrogen Peroxide™ (HHP™) technology directly into their material airlocks and existing transfer chambers—upgrading equipment they already own without major construction. And when an application calls for a dedicated, enclosed chamber, CURIS builds and controls a complete stainless steel system, too. Either way, the cycle, the controls, and the reporting stay CURIS.

Improve material throughput, reduce bottlenecks, and achieve repeatable, validated decontamination with automated chamber systems powered by CURIS Hybrid Hydrogen Peroxide™ technology.

Material transfer is one of the most critical—and often limiting—steps in contamination control.

In pharmaceutical cleanrooms, biosafety laboratories, and vivarium environments, manual spray-and-wipe processes introduce variability and increase labor demands.

CURIS decontamination chambers provide automated, repeatable biodecontamination cycles for materials, equipment, and components moving into controlled environments.

As part of the CURIS^® Integration Architecture™, chamber systems can be deployed at multiple levels—from controlled chamber operation to fully automated, facility-wide material transfer workflows.

Manual decontamination processes often become a constraint on facility performance.

CURIS chamber systems help facilities:

• Process higher volumes of materials per cycle
• Reduce reliance on manual wiping and staging processes
• Improve turnaround time between operations
• Minimize delays in production or research workflows

For high-throughput environments, automated chamber-based biodecontamination can significantly improve operational efficiency.

A biodecontamination chamber is an enclosed system that uses vaporized hydrogen peroxide (VHP / VPHP) to disinfect materials before they enter higher-grade or controlled environments.

CURIS chambers use Hybrid Hydrogen Peroxide™ technology (HHP™), delivering a combination of vapor and micro-aerosolized hydrogen peroxide for consistent surface coverage and sporicidal efficacy.

These systems are commonly used in:

• Material airlocks (MALs)
• Cleanroom material transfer
• Biosafety laboratory workflows (BSL-2 to BSL-4)
• Vivarium material and equipment movement

These systems are increasingly adopted as facilities move toward more automated and repeatable contamination control processes.

Automated chamber systems support consistent, compliant contamination control by providing:

• Repeatable, validated cycles
• Reduced operator variability and human error
• Improved documentation and compliance readiness
• Safer, controlled handling of incoming materials

Cycle Time and Throughput Performance

Cycle time is a key driver of material throughput, with CURIS chamber systems achieving:

• Validated biodecontamination cycles in under 60–90 minutes
• Faster turnaround with optimized aeration and airflow conditions

This supports more efficient operations and reduced downtime.

Low-Concentration Hydrogen Peroxide for Safer Operation

CURIS systems use a 7% hydrogen peroxide solution, significantly lower than traditional high-concentration systems.

This enables:

• Improved compatibility with sensitive materials and electronics
• Reduced risk to personnel and operators
• Faster aeration and return-to-operation times
• Lower environmental and facility impact

Chamber Integration Within the CURIS® Integration Architecture™

CURIS chamber systems are designed to align with different levels of facility integration.

Controlled Chamber Operation (Command™-Level Integration)

For facilities requiring structured, repeatable processes:

• Pre-programmed, automated biodecontamination cycles
• Integrated HMI touchscreen control
• Cycle monitoring, reporting, and audit tracking
• Coordination with facility systems such as HVAC and door interlocks

Best for:
Facilities seeking controlled, repeatable biodecontamination without full facility automation.

Fully Integrated Chamber Systems (Totalis™-Level Integration)

For facilities requiring advanced automation and throughput:

• Full integration with BAS/BMS systems
• Automated material transfer workflows
• Centralized control across multiple chambers or areas
• Support for lights-out or operator-initiated operation

Best for:
Facilities implementing high-throughput, fully automated contamination control strategies.

Integration with Leading Chamber Manufacturers

CURIS HHP™ technology integrates into your existing material airlocks and into third-party chamber platforms such as Buxton, Getinge, PBSC, and Spire—so you can upgrade or retrofit the equipment you already own. (Prefer a dedicated, purpose-built enclosure? CURIS also builds complete stainless steel chambers—see below.)

This enables facilities to:

• Upgrade or retrofit existing chamber systems
• Incorporate CURIS HHP™ technology into new equipment
• Align third-party systems with integrated biodecontamination strategies

Implementing a chamber-based biodecontamination system may involve coordination with facility infrastructure, including:

• HVAC operation and airflow management
• Room pressurization and containment
• Door sealing and interlock systems
• Environmental conditions such as temperature and humidity

CURIS works with facility and engineering teams to define requirements and support successful system implementation.

A Complete CURIS Chamber—Built and Controlled by CURIS

Some applications call for a dedicated chamber rather than integrating into existing equipment. A stainless steel chamber isn’t required with CURIS—the low-concentration Hybrid Hydrogen Peroxide™ technology works without one—but when you want a purpose-built enclosure, CURIS builds and controls the entire system.

When you want a turnkey system, CURIS provides a fully self-contained stainless steel biodecontamination chamber (example rendered below). The enclosure, vapor delivery, sensors, HMI touchscreen, cycle logic, and reporting are all engineered and controlled by CURIS—so you work with one source for the equipment, the decontamination cycle, and validation support.

What Sets a CURIS Chamber Apart

• Fully CURIS-controlled—the HMI and PLC are CURIS, so cycle logic, monitoring, and 21 CFR Part 11 reporting all run from one system
• Custom, U.S.-built stainless steel enclosure designed for sealed, repeatable cycles
• Gasketed, double-door (pass-through) design for sealed material transfer
• Integrated damper controls for airflow and containment
• Validated, repeatable HHP™ cycles

Already have a chamber you want to keep? CURIS technology also integrates into your existing equipment and third party platforms—see above.

System Scope and Integration Responsibilities

CURIS supports a range of integration approaches depending on facility needs.

Typical CURIS scope includes:

• Biodecontamination system and controls
• Injection and vapor delivery components
• HMI interfaces and reporting systems

With a complete CURIS stainless steel chamber, the enclosure, sealing, controls, vapor delivery, and reporting are all within CURIS scope—a single integrated system rather than technology added to another manufacturer’s equipment. Facility scope is limited to site utilities and connection points.

Facility or engineering scope may include:

• HVAC and airflow control systems
• Room construction and sealing
• Building automation system integration

CURIS collaborates closely with project teams to ensure alignment across all system components.

CURIS chamber systems can be implemented in both new and existing facilities:

• Existing material airlocks and transfer spaces
• Retrofit cleanroom environments
• New facility construction projects

CURIS supports two paths. Choose a complete CURIS stainless steel chamber for a purpose-built, fully controlled system—or integrate CURIS technology into existing material airlocks and transfer spaces when major construction isn’t needed. CURIS helps you select the right approach for your application.

CURIS chamber systems support a wide range of controlled environments, including:

Pharmaceutical & Biopharmaceutical Facilities

• Material airlocks for aseptic processing
• Fill-finish and production environments
• Isolator material transfer

Biosafety & Containment Laboratories

• BSL-2, BSL-3, and BSL-4 environments
• Equipment and material transfer workflows

Vivarium Facilities

• Cage and equipment transfer
• Animal room material movement

Biotechnology & Research Laboratories

• Controlled research environments
• Sensitive equipment and material handling

Explore Integrated Biodecontamination Systems

Chamber systems are one implementation of a broader approach to contamination control.

See how the CURIS^® Integration Architecture™ supports integrated biodecontamination across rooms, chambers, and entire facilities.

👉 Explore Integrated Biodecontamination Systems

Request a Chamber Integration Assessment or a Complete CURIS Chamber Quote

Discuss your material transfer, throughput, and contamination control requirements with a CURIS specialist.

Identify the right level of chamber integration for your facility—from controlled operation to fully automated workflows.

👉 Speak with a CURIS Integration Specialist